Neutralization of Inhibition of Tumor Growth
نویسنده
چکیده
The antagonism between compounds promoting and inhibiting growth has received increasing attention in the past few years. Recently, as the result of a series of investigations with growing animals and micro-organisms, the findings of Woods (8) on the interference of p-aminobenzoic acid with sulfanilamide action have been extended by Woolley (9). In the studies to be described here it has been possible to demonstrate antagonisms between structurally related, and in some cases unrelated, substances by using tumor growth and its inhibition to show these relationships. Assay by a method involving the growth of transplanted tumors in mice (2) has shown that various substances, such as inositol (3), Lactobacillus casei factor (4), and xanthopterin (5) are effective in inhibiting the growth of tumors. However, among the substances and extracts tested none was found that stimulated tumor growth. It therefore appears that the transplants were probably growing at an optimal rate. A method was then devised to demonstrate the possible growth-stimulating properties of various substances by measuring their interference with tumor growth inhibitors. This was accomplished by repressing the growth rate of a transplant by injecting mice intravenously with a suitable dose of a proved inhibitor, and at the same time with a suitable dose of the substance or extract to be tested for antagonistic activity, the amount of inhibitor neutralized being a measure of the degree of interference.
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تاریخ انتشار 2007